% Keizer-Levine Reduced Model, Fig 5.6 B %% Carol Lucas kap=1500; kam=28.8; kbp=1500; kbm=385.9; kcp=1.75; kcm=0.1; Ka=(kam/kap)^(1/4);Kb=(kbm/kbp)^(1/3);Kc=kcm/kcp; c=.1; %% Assume this is the starting C %% Then we can find what winf=Po1+Po2+C1 is and assume it's the most %% we will have to work with and won't change quickly since C2 is slow winfss=(1+(Ka/c)^4+(c/Kb)^3)/(1+(1/Kc)+(Ka/c)^4+(c/Kb)^3); c=[.1:.01:2.5]; peakPo= winfss*(1 + (c/Kb).^3)./(1+(Ka./c).^4+(c/Kb).^3); winf=(1+(Ka./c).^4+(c/Kb).^3)./(1+(1/Kc)+(Ka./c).^4+(c/Kb).^3); ssPo=winf.*(1 + (c/Kb).^3)./(1+(Ka./c).^4+(c/Kb).^3); figure(1);clf; plot(c,ssPo,c,peakPo);xlabel('[Ca2+]i');ylabel('Po');title('Figure 5.6 (B)');