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Chapter 5 Whole Cell Models
Arthur S. Sherman, Yue-Xian Li and Joel E. Keizer

5.1 Models of ER and PM calcium handling
5.1.1 Flux balance equations with rapid buffering
5.1.2 Expressions for the fluxes
5.2 Calcium oscillations in the bullfrog sympathetic ganglion neuron
5.2.1 Ryanodine receptor kinetics: the Keizer-Levine model
5.2.2 Bullfrog sympathetic ganglion neuron closed-cell model
5.2.3 Bullfrog sympathetic ganglion neuron open-cell model
5.3 The pituitary gonadotroph
5.3.1 The ER oscillator in a closed cell
5.3.2 Open-cell model with constant calcium influx
5.3.3 The plasma membrane oscillator
5.3.4 Bursting driven by the ER in the full model
5.4 The pancreatic beta-cell
5.4.1 Chay-Keizer model
5.4.2 Chay-Keizer with an ER
5.3 Exercises
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